| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LZTS1 (337-596) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:5000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LZTS1 |
| Gene ID: |
11178 |
| Uniprot ID: |
LZTS1_HUMAN |
| Immunogen Region: |
337-596 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 337-596 of human LZTS1 (NP_066300.1). |
| Immunogen Sequence: |
QLQQEKRQLRQELESLMKEQ DLLETKLRSYEREKTSFGPA LEETQWEVCQKSGEISLLKQ QLKESQTEVNAKASEILGLK AQLKDTRGKLEGLELRTQDL EGALRTKGLELEVCENELQR KKNEAELLREKVNLLEQELQ ELRAQAALARDMGPPTFPED VPALQRELERLRAELREERQ GHDQMSSGFQHERLVWKEEK EKVIQYQKQLQQSYVAMYQR NQRLEKALQQLARGDSAGE |
| Tissue Specificity | Highly expressed in testis, prostate, spleen, thymus, ovary and brain. Detected at lower levels in heart, placenta, small intestine, colon, liver, kidney, skeletal muscle and pancreas. Not detectable in primary tumors from breast and prostate and in many cancer cell lines. |
| Post Translational Modifications | Phosphorylated on serine residues. Hyperphosphorylated by the cAMP-dependent kinase PKA during cell-cycle progression. |
| Function | Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. |
| Protein Name | Leucine Zipper Putative Tumor Suppressor 1F37/Esophageal Cancer-Related Gene-Coding Leucine-Zipper MotifFez1 |
| Cellular Localisation | CytoplasmCell MembraneCell ProjectionDendritic SpinePostsynaptic DensitySynapseAssociated With The Plasma Membrane And With MicrotubulesDetected In Dendritic SpinesEspecially In The Postsynaptic Density |
| Alternative Antibody Names | Anti-Leucine Zipper Putative Tumor Suppressor 1 antibodyAnti-F37/Esophageal Cancer-Related Gene-Coding Leucine-Zipper Motif antibodyAnti-Fez1 antibodyAnti-LZTS1 antibodyAnti-FEZ1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
