Anti-LRRC32/GARP antibody [SAA0543] (STJA0027670)

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STJA0027670
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Covered by St John's Laboratory Guarantee

Host: Mouse
Applications: Blocking/ELISA/FC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-Transforming Growth Factor Beta Activator Lrrc32 is suitable for use in Universaling, ELISA and Flow Cytometry research applications.
Clonality : Monoclonal
Clone ID : SAA0543
Conjugation: Unconjugated
Isotype: IgG2ak
Formulation: 0.01M PBS, pH 7.4, 0.09% Sodium azide.
Purification: Protein A/G purified from cell culture supernatant.
Concentration: 1 mg/ml
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: LRRC32
Gene ID: 2615
Uniprot ID: LRC32_HUMAN
Function Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta. Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3).
Protein Name Transforming Growth Factor Beta Activator Lrrc32
Garpin
Glycoprotein A Repetitions Predominant
Garp
Leucine-Rich Repeat-Containing Protein 32
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Surface
Alternative Antibody Names Anti-Transforming Growth Factor Beta Activator Lrrc32 antibody
Anti-Garpin antibody
Anti-Glycoprotein A Repetitions Predominant antibody
Anti-Garp antibody
Anti-Leucine-Rich Repeat-Containing Protein 32 antibody
Anti-LRRC32 antibody
Anti-D11S833E antibody

Information sourced from Uniprot.org

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