Western blot analysis of the lysates from COLO205 cells using LRAT antibody.

Anti-LRAT antibody (111-160 aa) (STJ93952)

SKU:
STJ93952
£48.00 - £252.00
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Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Lecithin retinol acyltransferase (111-160 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: LRAT
Gene ID: 9227
Uniprot ID: LRAT_HUMAN
Immunogen Region: 111-160 aa
Specificity: LRAT Polyclonal Antibody detects endogenous levels of LRAT protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human LRAT at the amino acid range 111-160
Function Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A (Probable). LRAT plays a critical role in vision (Probable). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium.due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments (Probable). Required for the survival of cone photoreceptors and correct rod photoreceptor cell morphology.
Protein Name Lecithin Retinol Acyltransferase
Phosphatidylcholine--Retinol O-Acyltransferase
Database Links Reactome: R-HSA-2453864
Reactome: R-HSA-2453902
Reactome: R-HSA-975634
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Membrane Protein
Rough Endoplasmic Reticulum
Endosome
Multivesicular Body
Cytoplasm
Perinuclear Region
Present In The Rough Endoplasmic Reticulum And Multivesicular Body In Hepatic Stellate Cells
Present In The Rough Endoplasmic Reticulum And Perinuclear Region In Endothelial Cells
Alternative Antibody Names Anti-Lecithin Retinol Acyltransferase antibody
Anti-Phosphatidylcholine--Retinol O-Acyltransferase antibody
Anti-LRAT antibody

Information sourced from Uniprot.org

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