| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LLGL2 (921-1020) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:5000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LLGL2 |
| Gene ID: |
3993 |
| Uniprot ID: |
L2GL2_HUMAN |
| Immunogen Region: |
921-1020 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 921-1020 of human LLGL2 (NP_001026973.1). |
| Immunogen Sequence: |
FSLSTKWLVEPRCLVDSAET KNHRPGNGAGPKKAPSRARN SGTQSDGEEKQPGLVMERAL LSDERVLKEIQSTLEGDRGS GNWRSHRAAVGCSLSNGGAE |
| Post Translational Modifications | Phosphorylated at Ser-653 by PRKCI. Phosphorylation is enhanced during cell polarization induced by calcium. Phosphorylation may occur during the cell-cell contact-induced cell polarization and may contribute to the segregation of LLGL2 from the PRKCI/aPKC and PARD6B/Par-6 complex. |
| Function | Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. |
| Protein Name | Llgl Scribble Cell Polarity Complex Component 2HglLethal(2 Giant Larvae Protein Homolog 2 |
| Cellular Localisation | CytoplasmLocalized In The Perinuclear Structure And Faintly At The Cell-Cell Contacts Sites In The InterphaseLocalized At The Cell Periphery During MetaphaseCortical Localization In Mitotic CellsFound In The Lateral Region Of Polarized Epithelial Cells |
| Alternative Antibody Names | Anti-Llgl Scribble Cell Polarity Complex Component 2 antibodyAnti-Hgl antibodyAnti-Lethal(2 Giant Larvae Protein Homolog 2 antibodyAnti-LLGL2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
