• Immunofluorescence analysis of Daudi cells using CD85j Rabbit polyclonal antibody (STJ11104870) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
  • Western blot analysis of various lysates, using CD85j antibody (STJ11104870) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3s.

Anti-LILRB1 antibody (STJ11104870)

SKU:
STJ11104870

£112.50 - £522.50
Current Stock:
Host: Rabbit
Applications: WB/IF
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1 is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: LILRB1
Gene ID: 10859
Uniprot ID: LIRB1_HUMAN
Immunogen: Recombinant protein of human CD85j.
Tissue Specificity Expressed in B cells, monocytes and various dendritic cell (DC) subsets including myeloid, plasmacytoid and tolerogenic DCs (at protein level). Expressed in decidual macrophages (at protein level). Expressed in decidual NK cells (at protein level).
Post Translational Modifications Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.
Function Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide. Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells. Reprograms B cells toward an immune suppressive phenotype.
Protein Name Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1
Lir-1
Leukocyte Immunoglobulin-Like Receptor 1
Cd85 Antigen-Like Family Member J
Immunoglobulin-Like Transcript 2
Ilt-2
Monocyte/Macrophage Immunoglobulin-Like Receptor 7
Mir-7
Cd Antigen Cd85j
Database Links Reactome: R-HSA-198933
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 5: Secreted
Alternative Antibody Names Anti-Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1 antibody
Anti-Lir-1 antibody
Anti-Leukocyte Immunoglobulin-Like Receptor 1 antibody
Anti-Cd85 Antigen-Like Family Member J antibody
Anti-Immunoglobulin-Like Transcript 2 antibody
Anti-Ilt-2 antibody
Anti-Monocyte/Macrophage Immunoglobulin-Like Receptor 7 antibody
Anti-Mir-7 antibody
Anti-Cd Antigen Cd85j antibody
Anti-LILRB1 antibody
Anti-ILT2 antibody
Anti-LIR1 antibody
Anti-MIR7 antibody

Information sourced from Uniprot.org

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