Anti-LGMN antibody (26-288) (STJ112585)

Name: Anti-LGMN antibody (26-288) (STJ112585)
SKU: STJ112585
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ112585

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Short Description	Rabbit polyclonal LGMN (26-288) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.09% Sodium Azide, 50% Glycerol, pH7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	LGMN
Gene ID	5641
Uniprot ID	LGMN_HUMAN
Immunogen Region	26-288
Immunogen Sequence	GGKHWVVIVAGSNGWYNYRH QADACHAYQIIHRNGIPDEQ IVVMMYDDIAYSEDNPTPGI VINRPNGTDVYQGVPKDYTG EDVTPQNFLAVLRGDAEAVK GIGSGKVLKSGPQDHVFIYF TDHGSTGILVFPNEDLHVKD LNETIHYMYKHKMYRKMVFY IEACESGSMMNHLPDNINVY ATTAANPRESSYACYYDEKR STYLGDWYSVNWMEDSDVED LTKETLHKQYHLVKSHTNT
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 26-288 of human Legumain (LGMN) (NP_005597.3?).

Tissue Specificity	Ubiquitous. Particularly abundant in kidney, heart and placenta.
Post Translational Modifications	Activated by autocatalytic processing at pH 4.
Function	Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation.
Protein Name	Legumain Asparaginyl Endopeptidase Aep Protease - Cysteine 1
Database Links	Reactome: R-HSA-1679131 Reactome: R-HSA-196791 Reactome: R-HSA-2132295
Cellular Localisation	Lysosome
Alternative Antibody Names	Anti-Legumain antibody Anti-Asparaginyl Endopeptidase antibody Anti-Aep antibody Anti-Protease - Cysteine 1 antibody Anti-LGMN antibody Anti-PRSC1 antibody

Information sourced from Uniprot.org