| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LFNG (1-250) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LFNG |
| Gene ID: |
3955 |
| Uniprot ID: |
LFNG_HUMAN |
| Immunogen Region: |
1-250 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human LFNG (NP_002295.1). |
| Immunogen Sequence: |
MTPGRCCLAADIQVETFIFT DGEDEALARHTGNVVITNCS AAHSRQALSCKMAVEYDRFI ESGRKWFCHVDDDNYVNLRA LLRLLASYPHTRDVYVGKPS LDRPIQAMERVSENKVRPVH FWFATGGAGFCISRGLALKM SPWASGGHFMNTAERIRLPD DCTIGYIVEALLGVPLIRSG LFHSHLENLQQVPTSELHEQ VTLSYGMFENKRNAVHVKGP FSVEADPSRFRSIHCHLYP |
| Post Translational Modifications | A soluble form may be derived from the membrane form by proteolytic processing. |
| Function | Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1. Decreases the binding of JAG1 to NOTCH2 but not that of DLL1. Essential mediator of somite segmentation and patterning. |
| Protein Name | Beta-1 -3-N-Acetylglucosaminyltransferase Lunatic FringeO-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase |
| Database Links | Reactome: R-HSA-1912420Reactome: R-HSA-5083630Reactome: R-HSA-9824272 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Beta-1 -3-N-Acetylglucosaminyltransferase Lunatic Fringe antibodyAnti-O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase antibodyAnti-LFNG antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
