Anti-LEPREL2 antibody (487-736) (STJ116174)

SKU:
STJ116174

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Host: Rabbit
Applications: IHC
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-LEPREL2 (487-736) is suitable for use in Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: IHC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: P3H3
Gene ID: 10536
Uniprot ID: P3H3_HUMAN
Immunogen Region: 487-736
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 487-736 of human LEPREL2 (NP_055077.2).
Immunogen Sequence: DAAGAGARSGYRGRRSPHTP HERFEGLTVLKAAQLARAGT VGSQGAKLLLEVSERVRTLT QAYFSPERPLHLSFTHLVCR SAIEGEQEQRMDLSHPVHAD NCVLDPDTGECWREPPAYTY RDYSGLLYLNDDFQGGDLFF TEPNALTVTARVRPRCGRLV AFSSGVENPHGVWAVTRGRR CALALWHTWAPEHREQEWIE AKELLQESQEEEEEEEEEMP SKDPSPEPPSRRHQRVQDK
Tissue Specificity Detected in fetal cartilage (at protein level). Weak expression in heart, lung, ovary and skeletal muscle.
Function Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. Required for normal hydroxylation of lysine residues in type I collagen chains in skin, bone, tendon, aorta and cornea. Required for normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly. Apparently not required for normal prolyl 3-hydroxylation on collagen chains, possibly because it functions redundantly with other prolyl 3-hydroxylases.
Protein Name Prolyl 3-Hydroxylase 3
Leprecan-Like Protein 2
Protein B
Database Links Reactome: R-HSA-1650814
Cellular Localisation Endoplasmic Reticulum
Alternative Antibody Names Anti-Prolyl 3-Hydroxylase 3 antibody
Anti-Leprecan-Like Protein 2 antibody
Anti-Protein B antibody
Anti-P3H3 antibody
Anti-LEPREL2 antibody

Information sourced from Uniprot.org

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