| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LBR (1-211) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LBR |
| Gene ID: |
3930 |
| Uniprot ID: |
LBR_HUMAN |
| Immunogen Region: |
1-211 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-211 of human LBR (NP_002287.2). |
| Immunogen Sequence: |
MPSRKFADGEVVRGRWPGSS LYYEVEILSHDSTSQLYTVK YKDGTELELKENDIKPLTSF RQRKGGSTSSSPSRRRGSRS RSRSRSPGRPPKSARRSASA SHQADIKEARREVEVKLTPL ILKPFGNSISRYNGEPEHIE RNDAPHKNTQEKFSLSQESS YIATQYSLRPRREEVKLKEI DSKEEKYVAKELAVRTFEVT PIRAKDLEFGG |
| Tissue Specificity | Expressed in the bone marrow, liver, heart, adrenal gland, lung, placenta and uterus. Expressed in osteoclasts and osteoblast-like cells. |
| Post Translational Modifications | Phosphorylated by CDK1 in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures. Phosphorylation of LBR and HP1 proteins may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle. Phosphorylated by SRPK1. In late anaphase LBR is dephosphorylated, probably by PP1 and/or PP2A, allowing reassociation with chromatin. |
| Function | Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis. Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation. Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation. Anchors the lamina and the heterochromatin to the inner nuclear membrane. |
| Protein Name | Delta(14-Sterol Reductase LbrDelta-14-Sr3-Beta-Hydroxysterol Delta14-ReductaseC-14 Sterol ReductaseC14srIntegral Nuclear Envelope Inner Membrane ProteinLmn2rLamin-B ReceptorSterol C14-Reductase |
| Database Links | Reactome: R-HSA-191273Reactome: R-HSA-2995383Reactome: R-HSA-8980692Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013405Reactome: R-HSA-9013408Reactome: R-HSA-9013423Reactome: R-HSA-9022692 |
| Cellular Localisation | Nucleus Inner MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneCytoplasmNucleusNuclear Rim |
| Alternative Antibody Names | Anti-Delta(14-Sterol Reductase Lbr antibodyAnti-Delta-14-Sr antibodyAnti-3-Beta-Hydroxysterol Delta antibodyAnti-14-Reductase antibodyAnti-C-14 Sterol Reductase antibodyAnti-C14sr antibodyAnti-Integral Nuclear Envelope Inner Membrane Protein antibodyAnti-Lmn2r antibodyAnti-Lamin-B Receptor antibodyAnti-Sterol C14-Reductase antibodyAnti-LBR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
