| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KREMEN2 (200-360) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KREMEN2 |
| Gene ID: |
79412 |
| Uniprot ID: |
KREM2_HUMAN |
| Immunogen Region: |
200-360 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 200-360 of human KREMEN2 (NP_078783.1). |
| Immunogen Sequence: |
GQLCGGDGRLGVYEVSVGSC QGNWTAPQGVIYSPDFPDEY GPDRNCSWALGPPGAALELT FRLFELADPRDRLELRDAAS GSLLRAFDGARPPPSGPLRL GTAALLLTFRSDARGHAQGF ALTYRGLQDAAEDPEAPEGS AQTPAAPLDGANVSCSPRPG A |
| Function | Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. Plays a role in limb development.attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. |
| Protein Name | Kremen Protein 2Dickkopf Receptor 2Kringle Domain-Containing Transmembrane Protein 2Kringle-Containing Protein Marking The Eye And The Nose |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-3772470Reactome: R-HSA-5339717 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Kremen Protein 2 antibodyAnti-Dickkopf Receptor 2 antibodyAnti-Kringle Domain-Containing Transmembrane Protein 2 antibodyAnti-Kringle-Containing Protein Marking The Eye And The Nose antibodyAnti-KREMEN2 antibodyAnti-KRM2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
