| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KREMEN2 |
| Gene ID: | 79412 |
| Uniprot ID: | KREM2_HUMAN |
| Immunogen Region: | 200-360 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-360 of human KREMEN2 (NP_078783.1). |
| Immunogen Sequence: | GQLCGGDGRLGVYEVSVGSC QGNWTAPQGVIYSPDFPDEY GPDRNCSWALGPPGAALELT FRLFELADPRDRLELRDAAS GSLLRAFDGARPPPSGPLRL GTAALLLTFRSDARGHAQGF ALTYRGLQDAAEDPEAPEGS AQTPAAPLDGANVSCSPRPG A |
| Function | Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. Plays a role in limb development.attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. |
| Protein Name | Kremen Protein 2Dickkopf Receptor 2Kringle Domain-Containing Transmembrane Protein 2Kringle-Containing Protein Marking The Eye And The Nose |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-3772470Reactome: R-HSA-5339717 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Kremen Protein 2 antibodyAnti-Dickkopf Receptor 2 antibodyAnti-Kringle Domain-Containing Transmembrane Protein 2 antibodyAnti-Kringle-Containing Protein Marking The Eye And The Nose antibodyAnti-KREMEN2 antibodyAnti-KRM2 antibody |
Information sourced from Uniprot.org