• Western blot analysis of various lysates using KREMEN2 Rabbit polyclonal antibody (STJ118642) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 120s.

Anti-KREMEN2 antibody (200-360) (STJ118642)

SKU:
STJ118642

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Host: Rabbit
Applications: WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-KREMEN2 (200-360) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: KREMEN2
Gene ID: 79412
Uniprot ID: KREM2_HUMAN
Immunogen Region: 200-360
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 200-360 of human KREMEN2 (NP_078783.1).
Immunogen Sequence: GQLCGGDGRLGVYEVSVGSC QGNWTAPQGVIYSPDFPDEY GPDRNCSWALGPPGAALELT FRLFELADPRDRLELRDAAS GSLLRAFDGARPPPSGPLRL GTAALLLTFRSDARGHAQGF ALTYRGLQDAAEDPEAPEGS AQTPAAPLDGANVSCSPRPG A
Function Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. Plays a role in limb development.attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation.
Protein Name Kremen Protein 2
Dickkopf Receptor 2
Kringle Domain-Containing Transmembrane Protein 2
Kringle-Containing Protein Marking The Eye And The Nose
Database Links Reactome: R-HSA-201681
Reactome: R-HSA-3772470
Reactome: R-HSA-5339717
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Kremen Protein 2 antibody
Anti-Dickkopf Receptor 2 antibody
Anti-Kringle Domain-Containing Transmembrane Protein 2 antibody
Anti-Kringle-Containing Protein Marking The Eye And The Nose antibody
Anti-KREMEN2 antibody
Anti-KRM2 antibody

Information sourced from Uniprot.org

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