| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KLHDC2 |
| Gene ID: | 23588 |
| Uniprot ID: | KLDC2_HUMAN |
| Immunogen Region: | 306-406 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 306-406 of human KLHDC2 (NP_055130.1). |
| Immunogen Sequence: | EWIQFNHPYTEKPRLWHTAC ASDEGEVIVFGGCANNLLVH HRAAHSNEILIFSVQPKSLV RLSLEAVICFKEMLANSWNC LPKHLLHSVNQRFGSNNTSG S |
| Tissue Specificity | Widely expressed, with high levels in skeletal muscle, heart, pancreas and liver. Undetectable in peripheral blood leukocytes. |
| Function | Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(KLHDC2) complex specifically recognizes proteins with a diglycine (Gly-Gly) at the C-terminus, leading to their ubiquitination and degradation. The CRL2(KLHDC2) complex mediates ubiquitination and degradation of truncated SELENOK and SELENOS selenoproteins produced by failed UGA/Sec decoding, which end with a diglycine. The CRL2(KLHDC2) complex also recognizes proteolytically cleaved proteins ending with Gly-Gly, such as the N-terminal fragment of USP1, leading to their degradation. May also act as an indirect repressor of CREB3-mediated transcription by interfering with CREB3-DNA-binding. |
| Protein Name | Kelch Domain-Containing Protein 2 Hepatocellular Carcinoma-Associated Antigen 33 Host Cell Factor Homolog Lcp Host Cell Factor-Like Protein 1 Hclp-1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Kelch Domain-Containing Protein 2 antibody Anti-Hepatocellular Carcinoma-Associated Antigen 33 antibody Anti-Host Cell Factor Homolog Lcp antibody Anti-Host Cell Factor-Like Protein 1 antibody Anti-Hclp-1 antibody Anti-KLHDC2 antibody Anti-HCA33 antibody |
Information sourced from Uniprot.org