| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Kiss1 (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Kiss1 |
| Gene ID: |
280287 |
| Uniprot ID: |
KISS1_MOUSE |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of mouse Kiss1 (NP_839991.2). |
| Immunogen Sequence: |
MISMASWQLLLLLCVATYGE PLAKVAPLVKPGSTGQQSGP QELVNAWEKESRYAESKPGS AGLRARRSSPCPPVEGPAGR QRPLCASRSRLIPAPRGAVL |
| Tissue Specificity | Weak in all tissue types with highest levels in lung and 15- 17-day embryos. Expressed in areas of the hypothalamus implicated in the neuroendocrine regulation of gonadotropin secretion, including the anteroventral periventricular nucleus, the periventricular nucleus, and the arcuate nucleus. |
| Function | Metastasis suppressor protein. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Intracerebroventricular administration induces an increase in serum LH and FSH levels in prepubertal male and female as well as in adult animals. |
| Protein Name | Metastasis-Suppressor Kiss-1Kisspeptin-1 Cleaved Into - MetastinKisspeptin-52 - Kisspeptin-10Metastin45-54 |
| Database Links | Reactome: R-MMU-375276Reactome: -MMU-416476 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Metastasis-Suppressor Kiss-1 antibodyAnti-Kisspeptin-1 Cleaved Into - Metastin antibodyAnti-Kisspeptin-52 - Kisspeptin-10 antibodyAnti-Metastin45-54 antibodyAnti-Kiss1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
