| Host: | Mouse |
| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-KIM-1 is suitable for use in ELISA research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 10101 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative |
| Purification: | Greater than 95% purity |
| Concentration: | 5.0 mg/ml (+/-10 %) |
| Storage Instruction: | Unspecified, storage at 2–8°C. Temperature analysis:-70 °C, 21 days Not Determined (N/D)-20 °C, 14 days OK +4 °C, 14 days OK +35 °C, 14 days OK +45 °C, 7 days OK. Shelf life stability testing at 2–8 °C in the product buffer. |
| Association Rate Constant: | 2.1 x 106 1/Ms |
| Determination Method: | SPR analysis (ProteOn XPR36) |
| Immunoreactivity: | 80–120 % compared to the reference sample in an FIA test |
| Gene Symbol: | HAVCR1 |
| Gene ID: | 26762 |
| Uniprot ID: | HAVR1_HUMAN |
| Immunogen: | Human kidney injury molecule 1 |
| Tissue Specificity | Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses. |
| Post Translational Modifications | Ubiquitinated at two lysine residues Lys-338 and Lys-346 on its cytoplasmic domain. Ubiquitination promotes receptor endocytosis and target receptors for lysosomal degradation and termination of receptor signaling. (Microbial infection) Ubiquitination is required for Dengue virus endocytosis. |
| Function | Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions. As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses. Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease. Regulates also expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10. Acts as a regulator of T-cell proliferation. May play a role in kidney injury and repair. (Microbial infection) Acts as a receptor for Hepatitis A virus. (Microbial infection) Acts as a receptor for Ebolavirus and Marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane. Serves as a dual receptor for Ebolavirus by also interacting with envelope glycoprotein GP. (Microbial infection) Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane. TIM1 and Dengue virus are co-internalized during virus entry. (Microbial infection) Acts as a receptor for Zika virus by binding to envelope protein E. (Microbial infection) Plays a positive role in Chikungunya virus cell entry. |
| Protein Name | Hepatitis A Virus Cellular Receptor 1 Havcr-1 Kidney Injury Molecule 1 Kim-1 T-Cell Immunoglobulin And Mucin Domain-Containing Protein 1 Timd-1 T-Cell Immunoglobulin Mucin Receptor 1 Tim Tim-1 T-Cell Membrane Protein 1 Cd Antigen Cd365 |
| Database Links | Reactome: R-HSA-9694614 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Hepatitis A Virus Cellular Receptor 1 antibody Anti-Havcr-1 antibody Anti-Kidney Injury Molecule 1 antibody Anti-Kim-1 antibody Anti-T-Cell Immunoglobulin And Mucin Domain-Containing Protein 1 antibody Anti-Timd-1 antibody Anti-T-Cell Immunoglobulin Mucin Receptor 1 antibody Anti-Tim antibody Anti-Tim-1 antibody Anti-T-Cell Membrane Protein 1 antibody Anti-Cd Antigen Cd365 antibody Anti-HAVCR1 antibody Anti-KIM1 antibody Anti-TIM1 antibody Anti-TIMD1 antibody |
Information sourced from Uniprot.org