| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KIF2C |
| Gene ID: | 11004 |
| Uniprot ID: | KIF2C_HUMAN |
| Immunogen Region: | 1-190 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human KIF2C/MCAK (NP_006836.2). |
| Immunogen Sequence: | MAMDSSLQARLFPGLAIKIQ RSNGLIHSANVRTVNLEKSC VSVEWAEGGATKGKEIDFDD VAAINPELLQLLPLHPKDNL PLQENVTIQKQKRRSVNSKI PAPKESLRSRSTRMSTVSEL RITAQENDMEVELPAAANSR KQFSVPPAPTRPSCPAVAEI PLRMVSEEMEEQVHSIRGSS SANPVNSVRR |
| Tissue Specificity | Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary.expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas. Isoform 2 is testis-specific. |
| Post Translational Modifications | Phosphorylation by AURKB, regulates association with centromeres and kinetochores and the microtubule depolymerization activity. Ubiquitinated. |
| Function | In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment. |
| Protein Name | Kinesin-Like Protein Kif2c Kinesin-Like Protein 6 Mitotic Centromere-Associated Kinesin Mcak |
| Database Links | Reactome: R-HSA-141444 Reactome: R-HSA-2132295 Reactome: R-HSA-2467813 Reactome: R-HSA-2500257 Reactome: R-HSA-5663220 Reactome: R-HSA-6811434 Reactome: R-HSA-68877 Reactome: R-HSA-9648025 Reactome: R-HSA-983189 |
| Cellular Localisation | Cytoplasm Cytoskeleton Nucleus Chromosome Centromere Kinetochore Associates With The Microtubule Network At The Growing Distal Tip (The Plus-End) Of Microtubules Probably Through Interaction With Mtus2/Tip150 And Mapre1 Association With Microtubule Plus Ends Is Also Mediated By Interaction With Kif18b Centromeric Localization Requires The Presence Of Bub1 And Sgo2 |
| Alternative Antibody Names | Anti-Kinesin-Like Protein Kif2c antibody Anti-Kinesin-Like Protein 6 antibody Anti-Mitotic Centromere-Associated Kinesin antibody Anti-Mcak antibody Anti-KIF2C antibody Anti-KNSL6 antibody |
Information sourced from Uniprot.org