| Tissue Specificity | Detected in adult brain cortex and fetal frontal lobe (at protein level). Highly expressed in brain cortex, putamen, amygdala, hippocampus and cerebellum. |
| Post Translational Modifications | N-glycosylated. O-glycosylated. Shedding of the extracellular domain and intramembrane cleavage produce several proteolytic products. The intramembrane cleavage releases a soluble cytoplasmic polypeptide that translocates to the nucleolus. |
| Function | Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites. |
| Protein Name | Dyslexia-Associated Protein Kiaa0319 |
| Database Links | Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinEarly Endosome MembraneLow-Abundance Isoforms Lacking The Transmembrane Domain Have Been DescribedThese Are Secreted |
| Alternative Antibody Names | Anti-Dyslexia-Associated Protein Kiaa0319 antibodyAnti-KIAA0319 antibody |
Information sourced from Uniprot.org
