• Western blot analysis of various lysates using KIAA0319 Rabbit polyclonal antibody (STJ117564) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 5s.

Anti-KIAA0319 antibody (21-300) (STJ117564)

SKU:
STJ117564

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-KIAA0319 (21-300) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:200-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: KIAA0319
Gene ID: 9856
Uniprot ID: K0319_HUMAN
Immunogen Region: 21-300
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 21-300 of human KIAA0319 (NP_055624.2).
Immunogen Sequence: ARKQCSEGRTYSNAVISPNL ETTRIMRVSHTFPVVDCTAA CCDLSSCDLAWWFEGRCYLV SCPHKENCEPKKMGPIRSYL TFVLRPVQRPAQLLDYGDMM LNRGSPSGIWGDSPEDIRKD LTFLGKDWGLEEMSEYSDDY RELEKDLLQPSGKQEPRGSA EYTDWGLLPGSEGAFNSSVG DSPAVPAETQQDPELHYLNE SASTPAPKLPERSVLLPLPT TPSSGEVLEKEKASQLQEQ
Tissue Specificity Detected in adult brain cortex and fetal frontal lobe (at protein level). Highly expressed in brain cortex, putamen, amygdala, hippocampus and cerebellum.
Post Translational Modifications N-glycosylated. O-glycosylated. Shedding of the extracellular domain and intramembrane cleavage produce several proteolytic products. The intramembrane cleavage releases a soluble cytoplasmic polypeptide that translocates to the nucleolus.
Function Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites.
Protein Name Dyslexia-Associated Protein Kiaa0319
Database Links Reactome: R-HSA-8856825
Reactome: R-HSA-8856828
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Early Endosome Membrane
Low-Abundance Isoforms Lacking The Transmembrane Domain Have Been Described
These Are Secreted
Alternative Antibody Names Anti-Dyslexia-Associated Protein Kiaa0319 antibody
Anti-KIAA0319 antibody

Information sourced from Uniprot.org

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