| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Kdm6b (90-190) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KDM6B |
| Gene ID: |
23135 |
| Uniprot ID: |
KDM6B_HUMAN |
| Immunogen Region: |
90-190 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 90-190 of mouse KDM6B/JMJD3 (NP_001017426.1). |
| Immunogen Sequence: |
LESLHGCVQALLREPAQPGL WEQLGQLYESEHDSEEAVCC YHRALRYGGSFAELGPRIGR LQQAQLWNFHAGSCQHRAKV LPPLEQVWNLLHLEHKRNYG A |
| Function | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex. |
| Protein Name | Lysine-Specific Demethylase 6bJmjc Domain-Containing Protein 3Jumonji Domain-Containing Protein 3Lysine Demethylase 6bHistone H3-Trimethyl-L-Lysine(27 Demethylase 6b |
| Database Links | Reactome: R-HSA-2559580Reactome: R-HSA-3214842 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase 6b antibodyAnti-Jmjc Domain-Containing Protein 3 antibodyAnti-Jumonji Domain-Containing Protein 3 antibodyAnti-Lysine Demethylase 6b antibodyAnti-Histone H3-Trimethyl-L-Lysine(27 Demethylase 6b antibodyAnti-KDM6B antibodyAnti-JMJD3 antibodyAnti-KIAA0346 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
