| Host: |
Rabbit |
| Applications: |
WB/ELISA/IHC |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Potassium voltage-gated channel subfamily KQT member 4 (644-693 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNQ4 |
| Gene ID: |
9132 |
| Uniprot ID: |
KCNQ4_HUMAN |
| Immunogen Region: |
644-693 aa |
| Specificity: |
KCNQ4 Polyclonal Antibody detects endogenous levels of KCNQ4 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human KCNQ4 at the amino acid range 644-693 |
| Function | Pore-forming subunit of the voltage-gated potassium (Kv) channel involved in the regulation of sensory cells excitability in the cochlea. KCNQ4/Kv7.4 channel is composed of 4 pore-forming subunits assembled as tetramers. Promotes the outflow of potassium ions in the repolarization phase of action potential which plays a role in regulating membrane potential of excitable cells. The channel conducts a slowly activating and deactivating current. Current often shows some inward rectification at positive potentials. Channel may be selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) = Rb(+) > Cs(+) > Na(+). Important for normal physiological function of inner ear such as sensory perception of sound. |
| Protein Name | Potassium Voltage-Gated Channel Subfamily Kqt Member 4Kqt-Like 4Potassium Channel Subunit Alpha Kvlqt4Voltage-Gated Potassium Channel Subunit Kv7.4 |
| Database Links | Reactome: R-HSA-1296072Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | Basal Cell MembraneMulti-Pass Membrane ProteinSituated At The Basal Membrane Of Cochlear Outer Hair Cells |
| Alternative Antibody Names | Anti-Potassium Voltage-Gated Channel Subfamily Kqt Member 4 antibodyAnti-Kqt-Like 4 antibodyAnti-Potassium Channel Subunit Alpha Kvlqt4 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv7.4 antibodyAnti-KCNQ4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
