Western blot analysis of extracts of various cell lines, using KCNMB2 antibody (STJ112315) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-KCNMB2 antibody (68-194) (STJ112315)

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STJ112315
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: KCNMB2
Gene ID: 10242
Uniprot ID: KCMB2_HUMAN
Immunogen Region: 68-194
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 68-194 of human KCNMB2 (NP_005823.1).
Immunogen Sequence: TLLRSYMQSVWTEESQCTLL NASITETFNCSFSCGPDCWK LSQYPCLQVYVNLTSSGEKL LLYHTEETIKINQKCSYIPK CGKNFEESMSLVNVVMENFR KYQHFSCYSDPEGNQKSVIL TKLYSSN
Tissue Specificity Expressed in kidney, heart and brain. Highly expressed in ovary. Expressed at low level in other tissues.
Post Translational Modifications N-glycosylated.
Function Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons.
Protein Name Calcium-Activated Potassium Channel Subunit Beta-2
Bk Channel Subunit Beta-2
Bkbeta2
Hbeta2
Calcium-Activated Potassium Channel - Subfamily M Subunit Beta-2
Charybdotoxin Receptor Subunit Beta-2
Hbeta3
K(Vcabeta-2
Maxi K Channel Subunit Beta-2
Slo-Beta-2
Database Links Reactome: R-HSA-1296052
Reactome: R-HSA-418457
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Calcium-Activated Potassium Channel Subunit Beta-2 antibody
Anti-Bk Channel Subunit Beta-2 antibody
Anti-Bkbeta2 antibody
Anti-Hbeta2 antibody
Anti-Calcium-Activated Potassium Channel - Subfamily M Subunit Beta-2 antibody
Anti-Charybdotoxin Receptor Subunit Beta-2 antibody
Anti-Hbeta3 antibody
Anti-K(Vcabeta-2 antibody
Anti-Maxi K Channel Subunit Beta-2 antibody
Anti-Slo-Beta-2 antibody
Anti-KCNMB2 antibody

Information sourced from Uniprot.org

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