| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | KCNMA1 |
| Gene ID: | 3778 |
| Uniprot ID: | KCMA1_HUMAN |
| Immunogen Region: | 850-950 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 850-950 of human KCNMA1 (NP_001258447.1). |
| Immunogen Sequence: | SIGVLQANSQGFTPPGMDRS SPDNSPVHGMLRQPSITTGV NIPIITELVNDTNVQFLDQD DDDDPDTELYLTQPFACGTA FAVSVLDSLMSATYFNDNIL T |
| Tissue Specificity | Widely expressed. Except in myocytes, it is almost ubiquitously expressed. |
| Post Translational Modifications | Phosphorylated (Probable). Phosphorylation by kinases such as PKA and/or PKG. In smooth muscles, phosphorylation affects its activity. Palmitoylation by ZDHHC22 and ZDHHC23 within the intracellular linker between the S0 and S1 transmembrane domains regulates localization to the plasma membrane. Depalmitoylated by LYPLA1 and LYPLAL1, leading to retard exit from the trans-Golgi network. |
| Function | Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). Isoform 5: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). |
| Protein Name | Calcium-Activated Potassium Channel Subunit Alpha-1 Bk Channel Bkca Alpha Calcium-Activated Potassium Channel - Subfamily M Subunit Alpha-1 K(Vcaalpha Kca1.1 Maxi K Channel Maxik Slo-Alpha Slo1 Slowpoke Homolog Slo Homolog Hslo |
| Database Links | Reactome: R-HSA-1296052 Reactome: R-HSA-418457 Reactome: R-HSA-9662360 Reactome: R-HSA-9667769 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Calcium-Activated Potassium Channel Subunit Alpha-1 antibody Anti-Bk Channel antibody Anti-Bkca Alpha antibody Anti-Calcium-Activated Potassium Channel - Subfamily M Subunit Alpha-1 antibody Anti-K(Vcaalpha antibody Anti-Kca1.1 antibody Anti-Maxi K Channel antibody Anti-Maxik antibody Anti-Slo-Alpha antibody Anti-Slo1 antibody Anti-Slowpoke Homolog antibody Anti-Slo Homolog antibody Anti-Hslo antibody Anti-KCNMA1 antibody Anti-KCNMA antibody Anti-SLO antibody |
Information sourced from Uniprot.org
