| Tissue Specificity | Isoform A: Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. In brain, mainly expressed in cerebellum, occipital lobe, putamen, and thalamus. No expression is detected in amygdala and spinal cord. Isoform B: Strongly expressed in kidney (primarily in the proximal tubule) and pancreas. Isoform C: Abundantly expressed in brain. |
| Function | K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, acidic pH, heat and lipids. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties. In trigeminal ganglia sensory neurons, the heterodimer of KCNK10/TREK-2 and KCNK18/TRESK inhibits neuronal firing and neurogenic inflammation by stabilizing the resting membrane potential at K(+) equilibrium potential as well as by regulating the threshold of action potentials and the spike frequency. Permeable to other monovalent ions such as Rb(+) and Cs(+). |
| Protein Name | Potassium Channel Subfamily K Member 10Outward Rectifying Potassium Channel Protein Trek-2Trek-2 K(+ Channel Subunit |
| Database Links | Reactome: R-HSA-1299503Reactome: R-HSA-5576886 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Potassium Channel Subfamily K Member 10 antibodyAnti-Outward Rectifying Potassium Channel Protein Trek-2 antibodyAnti-Trek-2 K(+ Channel Subunit antibodyAnti-KCNK10 antibodyAnti-TREK2 antibody |
Information sourced from Uniprot.org
