| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KCNG4 |
| Gene ID: |
93107 |
| Uniprot ID: |
KCNG4_HUMAN |
| Immunogen Region: |
1-220 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human KCNG4 (NP_758857.1). |
| Immunogen Sequence: |
MPMPSRDGGLHPRHHHYGSH SPWSQLLSSPMETPSIKGLY YRRVRKVGALDASPVDLKKE ILINVGGRRYLLPWSTLDRF PLSRLSKLRLCRSYEEIVQL CDDYDEDSQEFFFDRSPSAF GVIVSFLAAGKLVLLQEMCA LSFQEELAYWGIEEAHLERC CLRKLLRKLEELEELAKLHR EDVLRQQRETRRPASHSSRW GLCMNRLREMVENPQSGLPG |
| Tissue Specificity | Highly expressed in brain, and at lower levels in liver, small intestine and colon. |
| Function | Regulatory subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1, modulates the kinetics parameters of the heterotetrameric channel namely the time course of activation, deactivation and inactivation and on the voltage-dependence of activation. Potassium channel subunit that does not form functional channels by itself (Probable). Reduces the deactivation rate. Modulates the threshold for activation by shifting by approximately 20 mV in hyperpolarizing direction. Markedly changes the inactivation by shifting the voltage dependence of inactivation by approximately 40 mV in hyperpolarizing direction. Acceleratee activation and enhances the time course of activation. |
| Protein Name | Voltage-Gated Potassium Channel Regulatory Subunit Kcng4Potassium Voltage-Gated Channel Subfamily G Member 4Voltage-Gated Potassium Channel Subunit Kv6.3Voltage-Gated Potassium Channel Subunit Kv6.4 |
| Database Links | Reactome: R-HSA-1296072 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinHas To Be Associated With Kcnb1 Or Possibly Another Partner To Get Inserted In The Plasma MembraneColocalizes With Kcnb1 At The Plasma MembraneRetains In The Endoplasmic Reticulum In The Absence Of Kcnb1 |
| Alternative Antibody Names | Anti-Voltage-Gated Potassium Channel Regulatory Subunit Kcng4 antibodyAnti-Potassium Voltage-Gated Channel Subfamily G Member 4 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv6.3 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv6.4 antibodyAnti-KCNG4 antibodyAnti-KCNG3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
