| Host: |
Rabbit |
| Applications: |
IHC/IF/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-KN motif and ankyrin repeat domain-containing protein 2 (351-400 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC 1:100-1:300IF 1:200-1:1000ELISA 1:40000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
KANK2 |
| Gene ID: |
25959 |
| Uniprot ID: |
KANK2_HUMAN |
| Immunogen Region: |
351-400 aa |
| Specificity: |
KANK2 Polyclonal Antibody detects endogenous levels of KANK2 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human KANK2 at the amino acid range 351-400 |
| Post Translational Modifications | Phosphorylated by casein kinase II upon estrogen stimulation. Phosphorylation induces the release by KANK2 of NCOA1 and its translocation to the nucleus where NCOA1 can activate gene transcription. |
| Function | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3. Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria. Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis. Involved in the negative control of vitamin D receptor signaling pathway. Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway. May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney. Through the Rho signaling pathway may also regulate cell proliferation. |
| Protein Name | Kn Motif And Ankyrin Repeat Domain-Containing Protein 2Ankyrin Repeat Domain-Containing Protein 25Matrix-Remodeling-Associated Protein 3Src-1-Interacting ProteinSipSrc-Interacting ProteinSrc1-Interacting Protein |
| Cellular Localisation | CytoplasmMitochondrion |
| Alternative Antibody Names | Anti-Kn Motif And Ankyrin Repeat Domain-Containing Protein 2 antibodyAnti-Ankyrin Repeat Domain-Containing Protein 25 antibodyAnti-Matrix-Remodeling-Associated Protein 3 antibodyAnti-Src-1-Interacting Protein antibodyAnti-Sip antibodyAnti-Src-Interacting Protein antibodyAnti-Src1-Interacting Protein antibodyAnti-KANK2 antibodyAnti-ANKRD25 antibodyAnti-KIAA1518 antibodyAnti-MXRA3 antibodyAnti-SIP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
