Host: | Goat |
Applications: | Pep-ELISA/IHC |
Reactivity: | Human/Mouse/Rat/Dog/Cow |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Goat polyclonal antibody anti-ITPR2 (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
Concentration: | 0.5 mg/mL |
Dilution Range: | IHC-3.75µg/mlELISA-antibody detection limit dilution 1:128000. |
Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Gene Symbol: | ITPR2 |
Gene ID: | 3709 |
Uniprot ID: | ITPR2_HUMAN |
Immunogen Region: | Internal |
Accession Number: | NP_002214.2 |
Specificity: | No cross-reactivity expected with other types of ITPR. |
Immunogen Sequence: | PIEESNILSPVQD |
Post Translational Modifications | Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release. |
Function | Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA. |
Protein Name | Inositol 1 -4 -5-Trisphosphate Receptor Type 2Ip3 Receptor Isoform 2Ip3r 2Insp3r2Type 2 Inositol 1 -4 -5-Trisphosphate ReceptorType 2 Insp3 Receptor |
Database Links | Reactome: R-HSA-112043Reactome: R-HSA-114508Reactome: R-HSA-139853Reactome: R-HSA-1489509Reactome: R-HSA-2029485Reactome: R-HSA-2871809Reactome: R-HSA-381676Reactome: R-HSA-4086398Reactome: R-HSA-422356Reactome: R-HSA-5218921Reactome: R-HSA-5578775Reactome: R-HSA-5607763Reactome: R-HSA-9664323Reactome: R-HSA-983695 |
Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
Alternative Antibody Names | Anti-Inositol 1 -4 -5-Trisphosphate Receptor Type 2 antibodyAnti-Ip3 Receptor Isoform 2 antibodyAnti-Ip3r 2 antibodyAnti-Insp3r2 antibodyAnti-Type 2 Inositol 1 -4 -5-Trisphosphate Receptor antibodyAnti-Type 2 Insp3 Receptor antibodyAnti-ITPR2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance