| Host: | Rabbit |
| Applications: | ELISA/WB |
| Reactivity: | Bovine/Human/Monkey/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-ITPR1 is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Biotin |
| Isotype: | IgG |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: | Affinity Purified |
| Concentration: | 0.52-0.63 µg/µl |
| Dilution Range: | WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | ITPR1 |
| Gene ID: | 3708 |
| Uniprot ID: | ITPR1_HUMAN |
| Immunogen: | Synthetic peptide corresponding to unique amino acid sequence on human ITPR subtype 1 protein. |
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Polyubiquitinated. Polyubiquitination targets ITPR1 for proteasomal degradation. Approximately 40% of the ITPR1-associated ubiquitin is monoubiquitin, and polyubiquitins are both 'Lys-48'- and 'Lys-63'-linked. Phosphorylated by cAMP kinase (PKA) enhances calcium release. Phosphorylation by PKA increases the interaction with inositol 1,4,5-trisphosphate and decreases the interaction with AHCYL1. Phosphorylated on tyrosine residues. Palmitoylated by ZDHHC6 in immune cells, leading to regulation of ITPR1 stability and function. |
| Function | Inositol 1,4,5-trisphosphate-gated calcium channel that, upon inositol 1,4,5-trisphosphate binding, mediates calcium release from the endoplasmic reticulum (ER). Undergoes conformational changes upon ligand binding, suggesting structural flexibility that allows the channel to switch from a closed state, capable of interacting with its ligands such as 1,4,5-trisphosphate and calcium, to an open state, capable of transferring calcium ions across the ER membrane. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CAMK2 complex. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Part of a complex composed of HSPA9, ITPR1 and VDAC1 that regulates mitochondrial calcium-dependent apoptosis by facilitating calcium transport from the ER lumen to the mitochondria intermembrane space thus providing calcium for the downstream calcium channel MCU that directly releases it into mitochondria matrix. Regulates fertilization and egg activation by tuning the frequency and amplitude of calcium oscillations. |
| Protein Name | Inositol 1 -4 -5-Trisphosphate-Gated Calcium Channel Itpr1 Ip3 Receptor Isoform 1 Ip3r 1 Insp3r1 Inositol 1 -4 -5 Trisphosphate Receptor Inositol 1 -4 -5-Trisphosphate Receptor Type 1 Type 1 Inositol 1 -4 -5-Trisphosphate Receptor Type 1 Insp3 Receptor |
| Database Links | Reactome: R-HSA-112043 Reactome: R-HSA-114508 Reactome: R-HSA-139853 Reactome: R-HSA-1489509 Reactome: R-HSA-2029485 Reactome: R-HSA-2871809 Reactome: R-HSA-381676 Reactome: R-HSA-4086398 Reactome: R-HSA-418457 Reactome: R-HSA-422356 Reactome: R-HSA-5218921 Reactome: R-HSA-5578775 Reactome: R-HSA-5607763 Reactome: R-HSA-9664323 Reactome: R-HSA-983695 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein Cytoplasmic Vesicle Secretory Vesicle Membrane Cytoplasm Perinuclear Region Found In A Complex With Hspa9 And Vdac1 At The Endoplasmic Reticulum-Mitochondria Contact Sites |
| Alternative Antibody Names | Anti-Inositol 1 -4 -5-Trisphosphate-Gated Calcium Channel Itpr1 antibody Anti-Ip3 Receptor Isoform 1 antibody Anti-Ip3r 1 antibody Anti-Insp3r1 antibody Anti-Inositol 1 -4 -5 Trisphosphate Receptor antibody Anti-Inositol 1 -4 -5-Trisphosphate Receptor Type 1 antibody Anti-Type 1 Inositol 1 -4 -5-Trisphosphate Receptor antibody Anti-Type 1 Insp3 Receptor antibody Anti-ITPR1 antibody Anti-INSP3R1 antibody |
Information sourced from Uniprot.org