| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ITM2C (1-220) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ITM2C |
| Gene ID: |
81618 |
| Uniprot ID: |
ITM2C_HUMAN |
| Immunogen Region: |
1-220 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ITM2C (NP_001012532.1). |
| Immunogen Sequence: |
MVKISFQPAVAGIKGDKADK ASASAPAPASATEILLTPAR LARDNFFRCGVLYEDSLSSQ VRTQMELEEDVKIYLDENYE RINVPVPQFGGGDPADIIHD FQRGLTAYHDISLDKCYVIE LNTTIVLPPRNFWELLMNVK RGTYLPQTYIIQEEMVVTEH VSDKEALGSFIYHLCNGKDT YRLRRRATRRRINKRGAKNC NAIRHFENTFVVETLICGVV |
| Tissue Specificity | High levels in the brain, specifically in the cerebral cortex, medulla, amygdala, hippocampus, thalamus, caudate nucleus, cerebellum, olfactory lobe and spinal cord. Very low levels in other organs. |
| Post Translational Modifications | Type I membrane-bound, as well as soluble, furin has a pre-eminent role in ITM2C proteolytic processing. PCSK7 and PCSK5 may also be involved although to a lesser extent. The soluble form of PCSK7 is incapable of processing ITM2C. Fails to undergo shedding by ADAM10 and intramembrane cleavage by SPPL2B. |
| Function | Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation. |
| Protein Name | Integral Membrane Protein 2cCerebral Protein 14Transmembrane Protein Bri3 Cleaved Into - Ct-Bri3 |
| Cellular Localisation | Lysosome MembraneSingle-Pass Type Ii Membrane ProteinCell Membrane |
| Alternative Antibody Names | Anti-Integral Membrane Protein 2c antibodyAnti-Cerebral Protein 14 antibodyAnti-Transmembrane Protein Bri3 Cleaved Into - Ct-Bri3 antibodyAnti-ITM2C antibodyAnti-BRI3 antibodyAnti-hucep-14 antibodyAnti-NPD018 antibodyAnti-PSEC0047 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
