| Host: |
Mouse |
| Applications: |
IHC-P |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Isocitrate Dehydrogenenase 1 IDH1-R132S is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
SMab-1 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1k |
| Formulation: |
Tissue culture supernatant with sodium azide |
| Concentration: |
Lot specific |
| Dilution Range: |
IHC-P 1:25-1:50 |
| Storage Instruction: |
Store at 2-8°C upon receipt. |
| Immunogen: |
KLH-conjugated peptide human IDH1-R132S |
| Background | Isocitrate dehydrogenase 1 (IDH1) is a 46 kDa NADPdependent enzyme, which catalyzes the decarboxylation of isocitrate into Alpha-ketoglutarate. IDH1 may also play a role in the prevention of oxidative damage, and the shuttling of proteins to peroxisomes. It is widely reported that mutations in IDH1 result in multiple forms of gliomas. The Arginine to Serine substitution at amino acid 132 is seen in gliomas, abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R (-)-2-hydroxyglutarate. |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Anti-Isocitrate Dehydrogenenase 1 IDH1-R132H antibody [HMab-1] (STJ16101369)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/151878/346963/STJ16101369_1__37596.1681999194.jpg?c=1 "Anti-Isocitrate Dehydrogenenase 1 IDH1-R132H antibody [HMab-1] (STJ16101369)")
