Host: |
Rabbit |
Applications: |
WB |
Reactivity: |
Human/Mouse |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-IL22 is suitable for use in Western Blot research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
Purification: |
Affinity purification |
Dilution Range: |
WB 1:500-1:1000 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
Il22 |
Gene ID: |
50929 |
Uniprot ID: |
IL22_MOUSE |
Immunogen: |
Recombinant protein of mouse IL22. |
Function | Cytokine that plays a critical role in modulating tissue responses during inflammation. Plays an essential role in the regeneration of epithelial cells to maintain barrier function after injury and for the prevention of further tissue damage. Unlike most of the cytokines, has no effect on immune cells. Signals through a heterodimeric receptor composed of two subunits, the specific receptor IL22RA1 which is present on non-immune cells in many organs and the shared subunit IL10RB. Ligation of IL22RA1 with IL22 induces activation of the tyrosine kinases JAK1 and TYK2, which in turn activates STAT3. In turn, promotes cell survival and proliferation through STAT3, ERK1/2 and PI3K/AKT pathways. Promotes phosphorylation of GSK3B at 'Ser-9' and CTTN. Promotes epithelial cell spreading. |
Protein Name | Interleukin-22Il-22Il-10-Related T-Cell-Derived-Inducible FactorIl-TifIl-Tif AlphaInterleukin-22aIl-22a |
Cellular Localisation | Secreted |
Alternative Antibody Names | Anti-Interleukin-22 antibodyAnti-Il-22 antibodyAnti-Il-10-Related T-Cell-Derived-Inducible Factor antibodyAnti-Il-Tif antibodyAnti-Il-Tif Alpha antibodyAnti-Interleukin-22a antibodyAnti-Il-22a antibodyAnti-Il22 antibodyAnti-Il22a antibodyAnti-Iltif antibodyAnti-Iltifa antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance