| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IL1RAPL1 (130-210) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IL1RAPL1 |
| Gene ID: |
11141 |
| Uniprot ID: |
IRPL1_HUMAN |
| Immunogen Region: |
130-210 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 130-210 of human IL1RAPL1 (NP_055086.1). |
| Immunogen Sequence: |
SISLTVGENDTGLCYNSKMK YFEKAELSKSKEISCRDIED FLLPTREPEILWYKECRTKT WRPSIVFKRDTLLIREVRED D |
| Tissue Specificity | Detected at low levels in heart, skeletal muscle, ovary, skin, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Detected at very low levels in tonsil, prostate, testis, small intestine, placenta, colon and fetal liver. |
| Function | May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth. During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD. |
| Protein Name | Interleukin-1 Receptor Accessory Protein-Like 1Il-1-Rapl-1Il-1rapl-1Il1rapl-1Oligophrenin-4Three Immunoglobulin Domain-Containing Il-1 Receptor-Related 2Tigirr-2X-Linked Interleukin-1 Receptor Accessory Protein-Like 1 |
| Database Links | Reactome: R-HSA-388844Reactome: R-HSA-9007892 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCytoplasmCell ProjectionAxonDendriteMay Localize To The Cell Body And Growth Cones Of Dendrite-Like Processes |
| Alternative Antibody Names | Anti-Interleukin-1 Receptor Accessory Protein-Like 1 antibodyAnti-Il-1-Rapl-1 antibodyAnti-Il-1rapl-1 antibodyAnti-Il1rapl-1 antibodyAnti-Oligophrenin-4 antibodyAnti-Three Immunoglobulin Domain-Containing Il-1 Receptor-Related 2 antibodyAnti-Tigirr-2 antibodyAnti-X-Linked Interleukin-1 Receptor Accessory Protein-Like 1 antibodyAnti-IL1RAPL1 antibodyAnti-OPHN4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
