| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IL16 (1-305) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IL16 |
| Gene ID: |
3603 |
| Uniprot ID: |
IL16_HUMAN |
| Immunogen Region: |
1-305 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-305 of human IL16 (NP_757366.2). |
| Immunogen Sequence: |
MESHSRAGKSRKSAKFRSIS RSLMLCNAKTSDDGSSPDEK YPDPFEISLAQGKEGIFHSS VQLADTSEAGPSSVPDLALA SEAAQLQAAGNDRGKTCRRI FFMKESSTASSREKPGKLEA QSSNFLFPKACHQRARSNST SVNPYCTREIDFPMTKKSAA PTDRQPYSLCSNRKSLSQQL DCPAGKAAGTSRPTRSLSTA QLVQPSGGLQASVISNIVLM KGQAKGLGFSIVGGKDSIY |
| Tissue Specificity | Isoform 3: Expressed in hemopoietic tissues, such as resting T-cells, but undetectable during active T-cell proliferation. |
| Post Translational Modifications | Isoform 3: Synthesized as a chemo-attractant inactive precursor in hemopoietic tissues, and proteolytically cleaved by caspase-3 to yield IL-16. |
| Function | Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 1: May act as a scaffolding protein that anchors ion channels in the membrane. Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells. |
| Protein Name | Pro-Interleukin-16 Cleaved Into - Interleukin-16Il-16Lymphocyte Chemoattractant FactorLcf |
| Database Links | Reactome: R-HSA-449836 |
| Cellular Localisation | Interleukin-16: SecretedIsoform 1: CytoplasmIsoform 3: CytoplasmNucleus |
| Alternative Antibody Names | Anti-Pro-Interleukin-16 Cleaved Into - Interleukin-16 antibodyAnti-Il-16 antibodyAnti-Lymphocyte Chemoattractant Factor antibodyAnti-Lcf antibodyAnti-IL16 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
