• Immunohistochemistry analysis of IL15 in paraffin-embedded rat lung usingIL15 Rabbit monoclonal antibody (STJ11104979) at dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of IL15 in paraffin-embedded human lung using IL15 Rabbit monoclonal antibody (STJ11104979) at dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of IL15 in paraffin-embedded human lung cancer using IL15 Rabbit monoclonal antibody (STJ11104979) at dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol

Anti-IL15 antibody (49-162) [S4979RM] (STJ11104979)

SKU:
STJ11104979

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Host: Rabbit
Applications: IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-Interleukin-15 (49-162) is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: S4979RM
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: IL15
Gene ID: 3600
Uniprot ID: IL15_HUMAN
Immunogen Region: 49-162
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 49-162 of human IL15 (NP_000576.1).
Immunogen Sequence: NWVNVISDLKKIEDLIQSMH IDATLYTESDVHPSCKVTAM KCFLLELQVISLESGDASIH DTVENLIILANNSLSSNGNV TESGCKECEELEEKNIKEFL QSFVHIVQMFINTS
Tissue Specificity Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15-S21AA is preferentially expressed in tissues such as testis and thymus.
Function Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems. Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines. In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection. Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits. Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5. In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4.
Protein Name Interleukin-15
Il-15
Database Links Reactome: R-HSA-8983432
Cellular Localisation Isoform Il15-S48aa: Secreted
Isoform Il15-S21aa: Cytoplasm
Nucleus
Il15-S21aa Is Not Secreted
But Rather Is Stored Intracellularly
Appearing In The Nucleus And Cytoplasmic Components
Alternative Antibody Names Anti-Interleukin-15 antibody
Anti-Il-15 antibody
Anti-IL15 antibody

Information sourced from Uniprot.org

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