| Tissue Specificity | Expressed on activated T-cells and resting memory T-cells. High expression seen in the thymic medulla and in the germinal centers and T-cell zones of lymph nodes and Peyer patches. Expressed at low levels in the spleen. |
| Post Translational Modifications | N-glycosylated. |
| Function | Stimulatory receptor expressed in activated or antigen-experienced T-cells that plays an important role in the immune response. Upon binding to its ligand ICOSL expressed on antigen presenting cells (APCs), delivers costimulatory signals that enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines including IL10, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Acts also as a costimulatory receptor critical for the differentiation of T follicular regulatory cells upon immune challenges such as viral infection. Mechanistically, potentiates TCR-induced calcium flux by augmenting PLCG1 activation and actin remodeling. In addition, activates PI3K signaling pathways independently of calcium flux. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes. |
| Protein Name | Inducible T-Cell CostimulatorActivation-Inducible Lymphocyte Immunomediatory MoleculeCd28 And Ctla-4-Like ProteinCclpCd28-Related Protein 1Crp-1Cd Antigen Cd278 |
| Database Links | Reactome: R-MMU-1257604Reactome: -MMU-388841Reactome: -MMU-6811558 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Inducible T-Cell Costimulator antibodyAnti-Activation-Inducible Lymphocyte Immunomediatory Molecule antibodyAnti-Cd28 And Ctla-4-Like Protein antibodyAnti-Cclp antibodyAnti-Cd28-Related Protein 1 antibodyAnti-Crp-1 antibodyAnti-Cd Antigen Cd278 antibodyAnti-Icos antibodyAnti-Ailim antibody |
Information sourced from Uniprot.org
