• Flow cytometric analysis of ICAM-1/CD54 Rabbit monoclonal antibody Cocotail (1:100 dilution) in Daudi cells (Orange) compare to rabbit IgG Isotype control (Blue) and non-staining control (Red).
  • Human peripheral blood lymphocytes co-stained with ICAM-1/CD54 Rabbit monoclonal antibody (10 Mu g/mL) and FITC conjugated goat anti-rabbit IgG and APC mouse anti-hCD19 monoclonal antibody (10 Mu g/mL).

Anti-ICAM1 antibody (28-480) [S3945RM] (STJ11103945)

SKU:
STJ11103945

£146.50 - £639.50
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Host: Rabbit
Applications: FC/IF
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-Intercellular Adhesion Molecule 1 (28-480) is suitable for use in Flow Cytometry and Immunofluorescence research applications.
Clonality: Monoclonal
Clone ID: S3945RM
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% thimerosal, pH7.3.
Purification: Affinity purification
Dilution Range: Elisa 1:500-1:2000
FC 1:50-1:200
IF/ICC 1:50-1:200
Storage Instruction: Store at 4°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ICAM1
Gene ID: 3383
Uniprot ID: ICAM1_HUMAN
Immunogen Region: 28-480
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 28-480 of human ICAM1. (NP_000192.2)
Immunogen Sequence: TSVSPSKVILPRGGSVLVTC STSCDQPKLLGIETPLPKKE LLLPGNNRKVYELSNVQEDS QPMCYSNCPDGQSTAKTFLT VYWTPERVELAPLPSWQPVG KNLTLRCQVEGGAPRANLTV VLLRGEKELKREPAVGEPAE VTTTVLVRRDHHGANFSCRT ELDLRPQGLELFENTSAPYQ LQTFVLPATPPQLVSPRVLE VDTQGTVVCSLDGLFPVSEA QVHLALGDQRLNPTVTYGN
Post Translational Modifications Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
Function ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.
Protein Name Intercellular Adhesion Molecule 1
Icam-1
Major Group Rhinovirus Receptor
Cd Antigen Cd54
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-216083
Reactome: R-HSA-6783783
Reactome: R-HSA-6785807
Reactome: R-HSA-877300
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Intercellular Adhesion Molecule 1 antibody
Anti-Icam-1 antibody
Anti-Major Group Rhinovirus Receptor antibody
Anti-Cd Antigen Cd54 antibody
Anti-ICAM1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance