| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HSPE1 (1-102) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HSPE1 |
| Gene ID: |
3336 |
| Uniprot ID: |
CH10_HUMAN |
| Immunogen Region: |
1-102 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-102 of human HSPE1/HSP10/CPN10 (NP_002148.1). |
| Immunogen Sequence: |
MAGQAFRKFLPLFDRVLVER SAAETVTKGGIMLPEKSQGK VLQATVVAVGSGSKGKGGEI QPVSVKVGDKVLLPEYGGTK VVLDDKDYFLFRDGDILGKY VD |
| Function | Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). |
| Protein Name | 10 Kda Heat Shock Protein - MitochondrialHsp1010 Kda ChaperoninChaperonin 10Cpn10Early-Pregnancy FactorEpf |
| Database Links | Reactome: R-HSA-9013408 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-10 Kda Heat Shock Protein - Mitochondrial antibodyAnti-Hsp10 antibodyAnti-10 Kda Chaperonin antibodyAnti-Chaperonin 10 antibodyAnti-Cpn10 antibodyAnti-Early-Pregnancy Factor antibodyAnti-Epf antibodyAnti-HSPE1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
