| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HSD17B6 |
| Gene ID: | 8630 |
| Uniprot ID: | H17B6_HUMAN |
| Immunogen Region: | 178-317 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 178-317 of human HSD17B6 (NP_003716.2). |
| Immunogen Sequence: | VSKYGVEAFSDILRREIQHF GVKISIVEPGYFRTGMTNMT QSLERMKQSWKEAPKHIKET YGQQYFDALYNIMKEGLLNC STNLNLVTDCMEHALTSVHP RTRYSAGWDAKFFFIPLSYL PTSLADYILTRSWPKPAQAV |
| Tissue Specificity | Detected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosum, hippocampus, substantia nigra and thalamus. Detected in fetal lung, liver and brain. |
| Function | NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids. |
| Protein Name | 17-Beta-Hydroxysteroid Dehydrogenase Type 6 17-Beta-Hsd 6 17-Beta-Hsd6 3-Alpha->Beta-Hydroxysteroid Epimerase 3-Alpha->Beta-Hse Oxidative 3-Alpha Hydroxysteroid Dehydrogenase Short Chain Dehydrogenase/Reductase Family 9c Member 6 |
| Database Links | Reactome: R-HSA-2453902 |
| Cellular Localisation | Microsome Membrane Peripheral Membrane Protein Lumenal Side Early Endosome Membrane |
| Alternative Antibody Names | Anti-17-Beta-Hydroxysteroid Dehydrogenase Type 6 antibody Anti-17-Beta-Hsd 6 antibody Anti-17-Beta-Hsd6 antibody Anti-3-Alpha->Beta-Hydroxysteroid Epimerase antibody Anti-3-Alpha->Beta-Hse antibody Anti-Oxidative 3-Alpha Hydroxysteroid Dehydrogenase antibody Anti-Short Chain Dehydrogenase/Reductase Family 9c Member 6 antibody Anti-HSD17B6 antibody Anti-RODH antibody Anti-SDR9C6 antibody |
Information sourced from Uniprot.org