| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HP (123-347) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HP |
| Gene ID: |
3240 |
| Uniprot ID: |
HPT_HUMAN |
| Immunogen Region: |
123-347 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 123-347 of human Haptoglobin (Haptoglobin (HP) ) (NP_001119574.1). |
| Immunogen Sequence: |
HHNLTTGATLINEQWLLTTA KNLFLNHSENATAKDIAPTL TLYVGKKQLVEIEKVVLHPN YSQVDIGLIKLKQKVSVNER VMPICLPSKDYAEVGRVGYV SGWGRNANFKFTDHLKYVML PVADQDQCIRHYEGSTVPEK KTPKSPVGVQPILNEHTFCA GMSKYQEDTCYGDAGSAFAV HDLEEDTWYATGILSFDKSC AVAEYGVYVKVTSIQDWVQK TIAEN |
| Tissue Specificity | Expressed by the liver and secreted in plasma. |
| Function | As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens. |
| Protein Name | HaptoglobinZonulin Cleaved Into - Haptoglobin Alpha Chain - Haptoglobin Beta Chain |
| Database Links | Reactome: R-HSA-2168880Reactome: R-HSA-6798695 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Haptoglobin antibodyAnti-Zonulin Cleaved Into - Haptoglobin Alpha Chain - Haptoglobin Beta Chain antibodyAnti-HP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
