| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HOOK2 (438-717) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HOOK2 |
| Gene ID: |
29911 |
| Uniprot ID: |
HOOK2_HUMAN |
| Immunogen Region: |
438-717 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 438-717 of human HOOK2 (NP_001093646.1). |
| Immunogen Sequence: |
LDPTSTPVDNLAAEILPAEL RETLLRLQLENKRLCRQEAA DRERQEELQRHLEDANRARH GLETQHRLNQQQLSELRAQV EDLQKALQEQGGKTEDSILL KRKLEEHLQKLHEADLELQR KREYIEELEPPTDSSTARRI EELQHNLQKKDADLRAMEER YRRYVDKARMVMQTMEPKQR PAAGAPPELHSLRTQLRERD VRIRHLEMDFEKSRSQREQE EKLLISAWYNMGMALQQRA |
| Function | Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell. |
| Protein Name | Protein Hook Homolog 2H-Hook2Hhk2 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeGolgi ApparatusTrans-Golgi NetworkColocalizes With AggresomesWhich Are Aggregates Of Misfolded ProteinsAt The CentrosomeAlso Localizes To Punctate Cytoplasmic Foci Which Do Not Appear To Overlap With Early Or Late EndosomesThe Endoplasmic ReticulumMultivesicular Bodies (Mvbs)LysosomeOr MitochondriaOften Found In Close Association With MicrotubulesLocalizes To The Manchette In Elongating Spermatids |
| Alternative Antibody Names | Anti-Protein Hook Homolog 2 antibodyAnti-H-Hook2 antibodyAnti-Hhk2 antibodyAnti-HOOK2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
