| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HJURP |
| Gene ID: |
55355 |
| Uniprot ID: |
HJURP_HUMAN |
| Immunogen Region: |
1-190 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human HJURP (NP_060880.3). |
| Immunogen Sequence: |
MLGTLRAMEGEDVEDDQLLQ KLRASRRRFQRRMQRLIEKY NQPFEDTPVVQMATLTYETP QGLRIWGGRLIKERNEGEIQ DSSMKPADRTDGSVQAAAWG PELPSHRTVLGADSKSGEVD ATSDQEESVAWALAPAVPQS PLKNELRRKYLTQVDILLQG AEYFECAGNRAGRDVRVTPL PSLASPAVPA |
| Tissue Specificity | highly expressed in the thymus with lower levels in the placenta, small intestine, liver, skeletal muscle, and colon. highly expressed in testis, and at a relatively lower level in thymus and bone marrow. Significantly overexpressed in many lung cancer samples, compared with normal lung. |
| Function | Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. |
| Protein Name | Holliday Junction Recognition Protein14-3-3-Associated Akt SubstrateFetal Liver-Expressing Gene 1 ProteinUp-Regulated In Lung Cancer 9 |
| Database Links | Reactome: R-HSA-606279 |
| Cellular Localisation | NucleusNucleolusChromosomeCentromereLocalizes In Centromeres During Late Telophase And Early G1When Cenpa Nucleosomes Are AssembledLocalizes To Nucleolus During S PhaseNucleolus Site Being Often Related To Storage |
| Alternative Antibody Names | Anti-Holliday Junction Recognition Protein antibodyAnti-14-3-3-Associated Akt Substrate antibodyAnti-Fetal Liver-Expressing Gene 1 Protein antibodyAnti-Up-Regulated In Lung Cancer 9 antibodyAnti-HJURP antibodyAnti-FAKTS antibodyAnti-FLEG1 antibodyAnti-URLC9 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
