Western blot analysis of extracts of various cell lines, using HERPUD1 antibody (STJ116032) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-HERPUD1 antibody (1-240) (STJ116032)

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STJ116032
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Host: Rabbit
Applications: WB/IHC-P/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
IHC-P:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: HERPUD1
Gene ID: 9709
Uniprot ID: HERP1_HUMAN
Immunogen Region: 1-240
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human HERPUD1 (NP_055500.1).
Immunogen Sequence: MESETEPEPVTLLVKSPNQR HRDLELSGDRGWSVGHLKAH LSRVYPERPRPEDQRLIYSG KLLLDHQCLRDLLPKQEKRH VLHLVCNVKSPSKMPEINAK VAESTEEPAGSNRGQYPEDS SSDGLRQREVLRNLSSPGWE NISRPEAAQQAFQGLGPGFS GYTPYGWLQLSWFQQIYARQ YYMQYLAATAASGAFVPPPS AQEIPVVSAPAPAPIHNQFP AENQPANQNAAPQVVVNPG
Tissue Specificity Widely expressed.in the brain, expression seems to be restricted to neurons and vascular smooth muscle cells. Present in activated microglia in senile plaques in the brain of patients with Alzheimer disease.
Function Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway.
Protein Name Homocysteine-Responsive Endoplasmic Reticulum-Resident Ubiquitin-Like Domain Member 1 Protein
Methyl Methanesulfonate
Mmf-Inducible Fragment Protein 1
Database Links Reactome: R-HSA-380994
Cellular Localisation Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Homocysteine-Responsive Endoplasmic Reticulum-Resident Ubiquitin-Like Domain Member 1 Protein antibody
Anti-Methyl Methanesulfonate antibody
Anti-Mmf-Inducible Fragment Protein 1 antibody
Anti-HERPUD1 antibody
Anti-HERP antibody
Anti-KIAA0025 antibody
Anti-MIF1 antibody

Information sourced from Uniprot.org

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