| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GUCY2F (250-460) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GUCY2F |
| Gene ID: |
2986 |
| Uniprot ID: |
GUC2F_HUMAN |
| Immunogen Region: |
250-460 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 250-460 of human GUCY2F (NP_001513.2). |
| Immunogen Sequence: |
HSALIGGETQMHLLECAHDL KMTDGTYVFVPYDALLYSLP YKHTPYRVLRNNPKLREAYD AVLTITVESQEKTFYQAFTE AAARGEIPEKLEFDQVSPLF GTIYNSIYFIAQAMNNAMKE NGQAGAASLVQHSRNMQFHG FNQLMRTDSNGNGISEYVIL DTNLKEWELHSTYTVDMEME LLRFGGTPIHFPGGRPPRAD AKCWFAEGKIC |
| Tissue Specificity | Retina. Localized exclusively in the outer nuclear layer and inner segments of the rod and cone photoreceptor cells. |
| Post Translational Modifications | There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds. |
| Function | Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment. May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane. |
| Protein Name | Retinal Guanylyl Cyclase 2Retgc-2Guanylate Cyclase 2f - RetinalGuanylate Cyclase FGc-FRod Outer Segment Membrane Guanylate Cyclase 2Ros-Gc2 |
| Database Links | Reactome: R-HSA-2514859 |
| Cellular Localisation | Photoreceptor Outer Segment MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Retinal Guanylyl Cyclase 2 antibodyAnti-Retgc-2 antibodyAnti-Guanylate Cyclase 2f - Retinal antibodyAnti-Guanylate Cyclase F antibodyAnti-Gc-F antibodyAnti-Rod Outer Segment Membrane Guanylate Cyclase 2 antibodyAnti-Ros-Gc2 antibodyAnti-GUCY2F antibodyAnti-GUC2F antibodyAnti-RETGC2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Immunofluorescence analysis of U-2 OS cells using [KO Validated] GIT1 Rabbit polyclonal antibody (STJ117632) at dilution of 1:100. Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/96591/379154/STJ117632_1__16196.1713146888.jpg?c=1 "Immunofluorescence analysis of U-2 OS cells using [KO Validated] GIT1 Rabbit polyclonal antibody (STJ117632) at dilution of 1:100. Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.")