| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GUCA1B (1-200) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GUCA1B |
| Gene ID: |
2979 |
| Uniprot ID: |
GUC1B_HUMAN |
| Immunogen Region: |
1-200 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human GUCA1B (NP_002089.4). |
| Immunogen Sequence: |
MGQEFSWEEAEAAGEIDVAE LQEWYKKFVMECPSGTLFMH EFKRFFKVTDDEEASQYVEG MFRAFDKNGDNTIDFLEYVA ALNLVLRGTLEHKLKWTFKI YDKDGNGCIDRLELLNIVEG IYQLKKACRRELQTEQGQLL TPEEVVDRIFLLVDENGDGQ LSLNEFVEGARRDKWVMKML QMDMNPSSWLAQQRRKSAMF |
| Tissue Specificity | In the retina, it is expressed in cone and rod photoreceptor cells. |
| Post Translational Modifications | The N-terminus is blocked. |
| Function | Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure. May be involved in cone photoreceptor response and recovery of response in bright light. |
| Protein Name | Guanylyl Cyclase-Activating Protein 2Gcap 2Guanylate Cyclase Activator 1b |
| Database Links | Reactome: R-HSA-2514859 |
| Cellular Localisation | Cell MembraneLipid-AnchorPhotoreceptor Inner SegmentCell ProjectionCiliumPhotoreceptor Outer SegmentSubcellular Location Is Not Affected By Light Or Dark Conditions |
| Alternative Antibody Names | Anti-Guanylyl Cyclase-Activating Protein 2 antibodyAnti-Gcap 2 antibodyAnti-Guanylate Cyclase Activator 1b antibodyAnti-GUCA1B antibodyAnti-GCAP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
