• Western blot of rat cerebellar lysate showing the specific immunolabeling of the ~95 kDa GRASP protein.

Anti-GRIPAP1 antibody (C-Term) (STJA0003669)

SKU:
STJA0003669-100

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Host: Rabbit
Applications: WB
Reactivity: Mouse/Rat/Bovine/Canine/Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-GRASP1 (C-Term) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol.
Purification: This antibody was antigen affinity purified from pooled serum.
Dilution Range: WB 1:1000
IHC
ICC
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Gripap1
Gene ID: 116493
Uniprot ID: GRAP1_RAT
Immunogen Region: C-Term
Immunogen: Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH.
Tissue Specificity Expressed in the central nervous system.especially in neurons.
Post Translational Modifications Proteolytically cleaved by caspase-3. A minor C-terminal proteolytic fragment of 30 kDa is produced. Proteolytic cleavage is required for JNK signaling activation.
Function Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity. GRASP-1 C-terminal chain: Functions as a scaffold protein in neurons to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity.
Protein Name Grip1-Associated Protein 1
Grasp-1 Cleaved Into - Grasp-1 C-Terminal Chain
30kda C-Terminus Form
Cellular Localisation Early Endosome Membrane
Peripheral Membrane Protein
Recycling Endosome Membrane
Cell Projection
Axon
Dendrite
Synapse
Localizes To Recycling Endosomal Tubules That Are Emanating From Early Endosomes
Alternative Antibody Names Anti-Grip1-Associated Protein 1 antibody
Anti-Grasp-1 Cleaved Into - Grasp-1 C-Terminal Chain antibody
Anti-30kda C-Terminus Form antibody
Anti-Gripap1 antibody
Anti-Grasp1 antibody

Information sourced from Uniprot.org

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