| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GRIN3B |
| Gene ID: |
116444 |
| Uniprot ID: |
NMD3B_HUMAN |
| Immunogen Region: |
180-410 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 180-410 of human GRIN3B (NP_619635.1). |
| Immunogen Sequence: |
RTQDPGGLVALWTSRAGRPP QLVLDLSRRDTGDAGLRARL APMAAPVGGEAPVPAAVLLG CDIARARRVLEAVPPGPHWL LGTPLPPKALPTAGLPPGLL ALGEVARPPLEAAIHDIVQL VARALGSAAQVQPKRALLPA PVNCGDLQPAGPESPGRFLA RFLANTSFQGRTGPVWVTGS SQVHMSRHFKVWSLRRDPRG APAWATVGSWRDGQLDLEPG GASARPPPPQG |
| Function | Component of a non-conventional N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with low calcium permeability and low voltage-dependent block by Mg(2+). Forms glutamatergic receptor complexes with GluN1 and GluN2 subunits which are activated by glycine binding to the GluN1 and GluN3 subunits and L-glutamate binding to GluN2 subunits. Forms excitatory glycinergic receptor complexes with GluN1 alone which are activated by glycine binding to the GluN1 and GluN3 subunits. GluN3B subunit also binds D-serine and, in the absence of glycine, activates glycinergic receptor complexes, but with lower efficacy than glycine. Each GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators. |
| Protein Name | Glutamate Receptor Ionotropic - Nmda 3bGlun3bN-Methyl-D-Aspartate Receptor Subtype 3bNmdar3bNr3b |
| Database Links | Reactome: R-HSA-9609736 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembraneRequires The Presence Of Grin1 To Be Targeted At The Plasma Membrane |
| Alternative Antibody Names | Anti-Glutamate Receptor Ionotropic - Nmda 3b antibodyAnti-Glun3b antibodyAnti-N-Methyl-D-Aspartate Receptor Subtype 3b antibodyAnti-Nmdar3b antibodyAnti-Nr3b antibodyAnti-GRIN3B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
