| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GNPTAB (42-350) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GNPTAB |
| Gene ID: |
79158 |
| Uniprot ID: |
GNPTA_HUMAN |
| Immunogen Region: |
42-350 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 42-350 of human GNPTAB (NP_077288.2). |
| Immunogen Sequence: |
LEWSRDQYHVLFDSYRDNIA GKSFQNRLCLPMPIDVVYTW VNGTDLELLKELQQVREQME EEQKAMREILGKNTTEPTKK SEKQLECLLTHCIKVPMLVL DPALPANITLKDLPSLYPSF HSASDIFNVAKPKNPSTNVS VVVFDSTKDVEDAHSGLLKG NSRQTVWRGYLTTDKEVPGL VLMQDLAFLSGFPPTFKETN QLKTKLPENLSSKVKLLQLY SEASVALLKLNNPKDFQEL |
| Tissue Specificity | Expressed in the heart, whole brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Post Translational Modifications | The alpha- and beta-subunits are generated by a proteolytic cleavage by MBTPS1 protease at the Lys-928-Asp-929 bond. |
| Function | Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment. |
| Protein Name | N-Acetylglucosamine-1-Phosphotransferase Subunits Alpha/BetaGlcnac-1-Phosphotransferase Subunits Alpha/BetaStealth Protein GnptabUdp-N-Acetylglucosamine-1-Phosphotransferase Subunits Alpha/Beta Cleaved Into - N-Acetylglucosamine-1-Phosphotransferase Subunit Alpha - N-Acetylglucosamine-1-Phosphotransferase Subunit Beta |
| Cellular Localisation | N-Acetylglucosamine-1-Phosphotransferase Subunit Alpha: Golgi Apparatus MembraneSingle-Pass Type I Membrane ProteinN-Acetylglucosamine-1-Phosphotransferase Subunit Beta: Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-N-Acetylglucosamine-1-Phosphotransferase Subunits Alpha/Beta antibodyAnti-Glcnac-1-Phosphotransferase Subunits Alpha/Beta antibodyAnti-Stealth Protein Gnptab antibodyAnti-Udp-N-Acetylglucosamine-1-Phosphotransferase Subunits Alpha/Beta Cleaved Into - N-Acetylglucosamine-1-Phosphotransferase Subunit Alpha - N-Acetylglucosamine-1-Phosphotransferase Subunit Beta antibodyAnti-GNPTAB antibodyAnti-GNPTA antibodyAnti-KIAA1208 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
