Western blot analysis of extracts of various cell lines, using GNPDA2 antibody (STJ111625) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-GNPDA2 antibody (1-190) (STJ111625)

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STJ111625
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:200-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GNPDA2
Gene ID: 132789
Uniprot ID: GNPI2_HUMAN
Immunogen Region: 1-190
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human GNPDA2 (NP_612208.1).
Immunogen Sequence: MRLVILDNYDLASEWAAKYI CNRIIQFKPGQDRYFTLGLP TGSTPLGCYKKLIEYHKNGH LSFKYVKTFNMDEYVGLPRN HPESYHSYMWNNFFKHIDID PNNAHILDGNAADLQAECDA FENKIKEAGGIDLFVGGIGP DGHIAFNEPGSSLVSRTRLK TLAMDTILANAKYFDGDLSK VPTMALTVGV
Tissue Specificity Ubiquitous, with highest expression detected in testis, ovary, placenta, and heart.
Function Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis. Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling.
Protein Name Glucosamine-6-Phosphate Isomerase 2
Glucosamine-6-Phosphate Deaminase 2
Gnpda 2
Glcn6p Deaminase 2
Glucosamine-6-Phosphate Isomerase Sb52
Database Links Reactome: R-HSA-70171
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Glucosamine-6-Phosphate Isomerase 2 antibody
Anti-Glucosamine-6-Phosphate Deaminase 2 antibody
Anti-Gnpda 2 antibody
Anti-Glcn6p Deaminase 2 antibody
Anti-Glucosamine-6-Phosphate Isomerase Sb52 antibody
Anti-GNPDA2 antibody
Anti-GNP2 antibody

Information sourced from Uniprot.org

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