| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GMPPB |
| Gene ID: | 29925 |
| Uniprot ID: | GMPPB_HUMAN |
| Immunogen Region: | 50-250 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-250 of human GMPPB (NP_068806.1). |
| Immunogen Sequence: | ILAVSYMSQVLEKEMKAQEQ RLGIRISMSHEEEPLGTAGP LALARDLLSETADPFFVLNS DVICDFPFQAMVQFHRHHGQ EGSILVTKVEEPSKYGVVVC EADTGRIHRFVEKPQVFVSN KINAGMYILSPAVLRRIQLQ PTSIEKEVFPIMAKEGQLYA MELQGFWMDIGQPKDFLTGM CLFLQSLRQKQPERLCSGPG I |
| Tissue Specificity | Isoform 1: Ubiquitously expressed, including in brain and skeletal muscle. Isoform 2: Weakly expressed with highest expression in skeletal muscle, brain and gonads. |
| Function | Catalytic subunit of the GMPPA-GMPPB mannose-1-phosphate guanylyltransferase complex. Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids. Can catalyze the reverse reaction in vitro. Together with GMPPA regulates GDP-alpha-D-mannose levels. |
| Protein Name | Mannose-1-Phosphate Guanylyltransferase Catalytic Subunit BetaGdp-Mannose Pyrophosphorylase BGtp-Mannose-1-Phosphate Guanylyltransferase Beta |
| Database Links | Reactome: R-HSA-446205 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Mannose-1-Phosphate Guanylyltransferase Catalytic Subunit Beta antibodyAnti-Gdp-Mannose Pyrophosphorylase B antibodyAnti-Gtp-Mannose-1-Phosphate Guanylyltransferase Beta antibodyAnti-GMPPB antibody |
Information sourced from Uniprot.org