| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GM2A (24-193) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GM2A |
| Gene ID: |
2760 |
| Uniprot ID: |
SAP3_HUMAN |
| Immunogen Region: |
24-193 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 24-193 of human GM2A (NP_000396.2). |
| Immunogen Sequence: |
HLKKPSQLSSFSWDNCDEGK DPAVIRSLTLEPDPIIVPGN VTLSVMGSTSVPLSSPLKVD LVLEKEVAGLWIKIPCTDYI GSCTFEHFCDVLDMLIPTGE PCPEPLRTYGLPCHCPFKEG TYSLPKSEFVVPDLELPSWL TTGNYRIESVLSSSGKRLGC IKIAASLKGI |
| Post Translational Modifications | The serines in positions 32 and 33 are absent in 80% of the sequenced protein. |
| Function | The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity. Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. Has cholesterol transfer activity. |
| Protein Name | Ganglioside Gm2 ActivatorCerebroside Sulfate Activator ProteinGm2-ApSphingolipid Activator Protein 3Sap-3 Cleaved Into - Ganglioside Gm2 Activator Isoform Short |
| Database Links | Reactome: R-HSA-1660662Reactome: R-HSA-6798695 |
| Cellular Localisation | Lysosome |
| Alternative Antibody Names | Anti-Ganglioside Gm2 Activator antibodyAnti-Cerebroside Sulfate Activator Protein antibodyAnti-Gm2-Ap antibodyAnti-Sphingolipid Activator Protein 3 antibodyAnti-Sap-3 Cleaved Into - Ganglioside Gm2 Activator Isoform Short antibodyAnti-GM2A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
