| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GDF3 |
| Gene ID: | 9573 |
| Uniprot ID: | GDF3_HUMAN |
| Immunogen Region: | 251-364 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 251-364 of human GDF3 (NP_065685.1). |
| Immunogen Sequence: | AAIPVPKLSCKNLCHRHQLF INFRDLGWHKWIIAPKGFMA NYCHGECPFSLTISLNSSNY AFMQALMHAVDPEIPQAVCI PTKLSPISMLYQDNNDNVIL RHYEDMVVDECGCG |
| Post Translational Modifications | Synthesized as large precursor molecule that undergo proteolytic cleavage, releasing the pro-domain from the active, receptor binding, C-terminal region of the molecule. |
| Function | Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor CRIPTO. Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and CRIPTO/Cripto. |
| Protein Name | Growth/Differentiation Factor 3Gdf-3 |
| Cellular Localisation | SecretedCytoplasmMainly Accumulated In The Cytoplasm |
| Alternative Antibody Names | Anti-Growth/Differentiation Factor 3 antibodyAnti-Gdf-3 antibodyAnti-GDF3 antibodyAnti-UNQ222 antibodyAnti-PRO248 antibody |
Information sourced from Uniprot.org