Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit monoclonal antibody anti-Folate Receptor Alpha (1-100) is suitable for use in Western Blot research applications. |
Clonality: | Monoclonal |
Clone ID: | S4857RM |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:1000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | FOLR1 |
Gene ID: | 2348 |
Uniprot ID: | FOLR1_HUMAN |
Immunogen Region: | 1-100 |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Folate Binding Protein (FBP) /FOLR1 (NP_000793.1). |
Immunogen Sequence: | MAQRMTTQLLLLLVWVAVVG EAQTRIAWARTELLNVCMNA KHHKEKPGPEDKLHEQCRPW RKNACCSTNTSQEAHKDVSY LYRFNWNHCGEMAPACKRHF |
Tissue Specificity | Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium. |
Post Translational Modifications | The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. |
Function | Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. |
Protein Name | Folate Receptor Alpha Fr-Alpha Adult Folate-Binding Protein Fbp Folate Receptor 1 Folate Receptor - Adult Kb Cells Fbp Ovarian Tumor-Associated Antigen Mov18 |
Database Links | Reactome: R-HSA-204005 Reactome: R-HSA-5694530 Reactome: R-HSA-6807878 |
Cellular Localisation | Cell Membrane Lipid-Anchor Gpi-Anchor Apical Cell Membrane Basolateral Cell Membrane Gpi-Like-Anchor Secreted Cytoplasmic Vesicle Clathrin-Coated Vesicle Endosome Endocytosed Into Cytoplasmic Vesicles And Then Recycled To The Cell Membrane |
Alternative Antibody Names | Anti-Folate Receptor Alpha antibody Anti-Fr-Alpha antibody Anti-Adult Folate-Binding Protein antibody Anti-Fbp antibody Anti-Folate Receptor 1 antibody Anti-Folate Receptor - Adult antibody Anti-Kb Cells Fbp antibody Anti-Ovarian Tumor-Associated Antigen Mov18 antibody Anti-FOLR1 antibody Anti-FOLR antibody |
Information sourced from Uniprot.org